Applications of polymers in drug delivery by Ambikanandan Misra, Aliasgar Shahiwala

By Ambikanandan Misra, Aliasgar Shahiwala

Use of polymers has turn into essential within the box of drug supply. Polymers play a vital position in modulating drug supply to use greatest healing merits and feature been primary within the winning improvement of numerous novel drug supply structures which are now available.

This publication offers information of the purposes of polymeric drug supply platforms that might be of curiosity to researchers in industries and academia. It describes the improvement of polymeric structures starting from the normal dosage kinds as much as the latest shrewdpermanent structures. The regulatory and highbrow estate features in addition to the scientific applicability of polymeric drug supply platforms also are discussed.

Each assorted drug supply course is mentioned in a separate bankruptcy of the e-book. All significant routes of drug supply were coated to supply the reader with a wide ranging in addition to an in-depth view of the advancements in polymer-based drug supply platforms. Appendices are integrated which comprise valuable pharmaceutical homes of the polymers and demanding polymeric purposes for numerous drug supply routes.

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2 Diffusion Controlled Diffusion controlled drug delivery systems involve the dispersion of the therapeutic agent within a polymer shell such as a macromolecule. The sustained release of therapeutic agent by this system is driven by diffusion and the drug is released either by passing through the pores or between polymer chains. The pores are usually created by water intrusion through the polymeric shell. These are the processes that control the release rate. The ease of preparation and commercial success of intra-uterine contraceptives such as Progestasert®, Norplant®, and various transdermal patches such as NicoDerm® and Transderm Nitro® have triggered intense research in this field.

Upon contact with gastric fluid, these gel formers, polysaccharides and polymers hydrate and form a colloidal gel barrier that controls the rate of fluid penetration into the device and subsequent drug release. As the exterior surface of the dosage form dissolves, the gel layer is maintained by the hydration of the adjacent hydrocolloid layer. The air trapped by 18 Polymers in Drug Delivery Systems the swollen polymer lowers the density and confers buoyancy to the dosage form [38, 39]. 4. 2 Hydrodynamically Balanced Systems These are single unit dosage form, containing one or more gel forming hydrophilic polymers, HPMC is the most commonly used excipient, although HEC, HPC, sodium CMC, agar and alginic acid are also used.

The ease of preparation and commercial success of intra-uterine contraceptives such as Progestasert®, Norplant®, and various transdermal patches such as NicoDerm® and Transderm Nitro® have triggered intense research in this field. 5 Applications of Polymers in Drug Delivery In diffusion-controlled release, diffusion of drug molecules within an aqueous solution is inhibited by the insoluble polymer matrix, in which drug molecules must travel through intricate pathways to exit the dosage form. Polymeric chains such as those in a crosslinked hydrogel form the diffusion barrier.

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