Current topics in membranes: Mechanosensitive Ion Channels: by Owen P. Hamill, Sidney A. Simon, Dale J. Benos

By Owen P. Hamill, Sidney A. Simon, Dale J. Benos

Current themes in Membranes offers a scientific, finished, and rigorous method of particular subject matters suitable to the learn of mobile membranes. each one quantity is a visitor edited compendium of membrane biology. This sequence has been a mainstay for working towards scientists and scholars drawn to this serious box of biology. Articles coated within the quantity comprise ENaC Proteins in Vascular tender Muscle Mechanotransduction; rules of the Mechano-Gated K2P Channel TREK-1 via Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a possible Mechanosensory Mechanism. classes From Polycystin-2 (TRPP2); Lipid pressure at Play: Mechanosensitivity of Voltage-Gated Channels; Hair cellphone Mechanotransduction: The Dynamic interaction among constitution and serve as; Pharmacology of Hair mobile MS Channels; Hair cellphone Mechanotransduction; versions of Hair mobilephone Mechanotrasduction; contact; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells;
MS Channels in Tumor telephone Migration; Mechanosensitive Channels in Regulating tender Muscle Contraction within the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

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Extra info for Current topics in membranes: Mechanosensitive Ion Channels: Part A

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Mechanosensitive channels of Escherichia coli: The MscL gene, protein, and activities. Annu. Rev. Physiol. 59, 633–657. Sukharev, S. , Sigurdson, W. , and Sachs, F. (1999). Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. J. Gen. Physiol. 113, 525–539. Terpe, K. (2003). Overview of tag protein fusions: From molecular and biochemical fundamentals to commerical systems. Appl. Microbiol. Biotechnol. 60, 523–533. Weiss, T. F. (1996). ‘‘Cellular Biophysics, Vol.

Science 290, 481–486. , and Tate, C. G. (1995). Overexpression of integral membrane proteins for structural studies. Q. Rev. Biophys. 28, 315–422. , and Tate, C. G. (2003). Preface: Overexpression of integral membrane proteins. Biochim. Biophys. Acta 1610, 1. , and Kaback, H. R. (2006). Manipulating phospholipids for crystallization of a membrane protein. Proc. Natl. Acad. Sci. USA 103, 1723–1726. Hamill, O. , and Martinac, B. (2001). Molecular basis of mechanotransduction in living cells. Physiol.

Acknowledgments We would like to acknowledge the contributions of Rob Spencer, GeoVrey Chang, Allen Lee, and Meg Barclay in launching the studies described in this chapter, and Yan Poon, Zhenfeng Liu, Chris Gandhi, and JeV Lai for continuing these eVorts. Discussions with Rob Phillips, Eduardo Perozo, Dennis Dougherty, Henry Lester, and Jim Howard are gratefully acknowledged. B. , and Sukharev, S. (2005). The ‘‘dashpot’’ mechanism of stretch‐ dependent gating in MscS. J. Gen. Physiol. 125, 143–154.

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